Laboratory work 2 – Determination of the theoretical and practical output of hexamethylenetetramine

The output of the drug should be about 70% of the theoretically calculated.

 

Quantity of finished product, g

η = ______________________________ х 100 %

Quantity of starting material, g

 

 

losses, g

έ (spending) = _______________________________ х 100 %

Quantity of starting material, g

Quantity of starting material, g

К expense = __________________________

Quantity of finished product, g

Topic 5- The technology of obtaining synthetic medical substances (6 hours)

Objective: To master the technology for obtaining and manufacturing organic drugs.

Learning objectives:

1. Apply some of the techniques for the synthesis in the laboratory.

2. Practice basis physical methods for processing drugs (filtration, crystallisation, distillation, redistillation, preparation of saturated solutions, etc.).

 

The main issue in this topic:

1. Common methods of work in chemical synthesis.
2. Admission calculate the theoretical yield of the drug, if possible, the expected yield on the conditions of synthesis of drugs.
3. Analysis methods for the synthesis of hexamethylenetetramine

 

Methods of learning and teaching: analysis of theoretical issues and practical tasks on the synthesis of organic medicinal substances.

 

References:

1. Альбицкая В.Г., Гинзбург О.Ф., Коляскина З.Н., Купин Б.С., Павлова Л.А., Разумова Н.А., Ралль К.Б., Серкова В.И., Стадничук М.Д. Лабораторные работы по органической химии. Под ред. О.Ф. Гинзбурга, А.А. Петрова. М.: Высш. шк., 1967. – 295 с.

2. Майофис Л.С. Химия и технология химико-фармацевтических препаратов. 2-е изд., перераб. и доп. – М.: Медицина, 1964. – 625 с.